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To focus on oxidative stress as a main damaging factor in an in vitro model is reasonable, as the diverse upstream causes for PN (hyperglycemia, dyslipidemia, some chemotherapeutics, alcohol abuse) converge into one prominent metabolic disturbance: the production of ROS and, thus, increased oxidative stress

doi:10.1056/NEJM200003233421205

It is a quinolinium salt substituted at position 5 with an amino group and at position 1 with a methyl group

Its unique mitochondrial origin and profound effects on glucose metabolism, insulin sensitivity, exercise capacity, and cellular resilience highlight the compelling mots-c peptide benefits that continue to emerge from rigorous research